Rajiv G. Menon1,
Edward G. Walsh2, Donald B. Twieg3, Timothy J. Carroll1,
4
1Radiology
Department, Feinberg School of Medicine, Northwestern University, Chicago,
IL, United States; 2Neuroscience, Brown University, Providence,
RI, United States; 3Biomedical Engineering, University of Alabama
at Birmingham, Birmingham, AL, United States; 4Biomedical
Engineering, Northwestern University, Chicago, IL, United States
Oxygen extraction fraction (OEF) is shown to be an independent predictor of stroke. There is an unmet clinical need for a robust MR based OEF measurement technique. A novel PARSE (Parameter Assessment by Retrieval from Signal Encoding) MRI based technique is reported here to measure OEF. We tested the technique on 5 normal subjects and provide anecdotal evidence on an AVM (Arterio-Venous Malformation) patient. Calculated PARSE MR-OEF correlate well with published Positron Emission Tomography (PET) data. Further clinical validation on subjects is required to establish the efficacy of this technique to clinically diagnose stroke risk in a patient.