Mansi B. Parekh1, Robert Fisher2, Kevin Graber2, Ryan Purcell, Rishi Raman, Leandro Bouzon, Scott Atlas1, Samantha J. Holdsworth1, Stefan Skare1, Rolland Bammer1, Michael Zeineh1
1Radiology, Stanford University, Stanford, CA, United States; 2Neurology & Neurological Sciences, Stanford University, Stanford, CA, United States
Discerning the microstructural abnormalities of the epileptogenic focus are not always possible with conventional MRI in patients with epilepsy. However, ultra-high resolution diffusion tensor imaging (DTI) may provide adequate microanatomical information to study subtle structural changes that underlie the epileptogenic focus. Recent published work from our group has shown promise in being able to study the mesial temporal lobe (MTL) structures using DTI. In this study, we further study fractional anisotropy, mean diffusivity and connectivity changes in the MTL structures of patients with unilateral mesial temporal sclerosis.