Udunna Anazodo1, 2, R. Stodika1, 2, John Butler1, Jonathan Mandel3, Terry Thompson1, 2, F.S Prato1, 2, Danny J.J. Wang4, Keith, S St. Lawrence1, 2
1Lawson Health Research Institute, London, Ontario, Canada; 2Medical Biophysics, Western University, London, Ontario, Canada; 3Radiology Department, St Joseph's Health Care, London, Ontario, Canada; 4Department of Neurology, UCLA, Ahmanson-Lovelace Brain Mapping Center, Los Angeles, CA, United States
Objective of this study was to investigate the ability of a hybrid PET/MRI scanner to collect whole-brain images of cerebral perfusion and metabolism simultaneously by combining pseudo-continuous ASL with PET imaging of fluorine-18 fluoro-deoxyglucose (FDG) imaging. A strong correlation between regional cerebral blood flow and energy metabolism was found in two neurologically normal patients and one patient with traumatic brain injury. A perfusion/metabolism mismatch was found in a patient with frontotemporal dementia, similar to previous studies of Alzhemiers disease.