Rui Wang1, Songlin Yu2, Jeffry R. Alger3, Bo Wang1, Jizong Zhao2, Zhentao Zuo1, Rong Xue1, Danny J.J. Wang3
1State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; 2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; 3Department of Neurology, University of California Los Angeles, Los Angeles, CA, United States
The goal of this study was to present a novel multi-delay multi-parametric pseudo-continuous ASL (pCASL) protocol which allows simultaneous estimation of cerebral blood flow (CBF), arterial cerebral blood volume and arterial transit time (ATT). Its accuracy was compared with CT perfusion (CTP) in 17 moyamoya patients. Based on both intra- and inter-subject correlation analysis, pCASL and CTP provided highly consistent results for the evaluation of hemodynamics in moyamoya patients. By incorporating delayed ATT in CBF calculation, pCASL is able to provide quantitative multi-parametric perfusion imaging consistent with CTP in moyamoya disease.