Chin-Tien Lu1, Tzu-Chen Yeh2, Fu-Nien Wang1
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; 2Department of Radiology, Taipei Veterans General Hospital , Taipei, Taiwan
D2O can be used as a free diffusible tracer for measurement of tissue perfusion. Recently, an indirect strategy for D2O perfusion MRI was proposed by monitoring the 1H signal attenuation. In this study, we aimed to further utilize the characteristic of long time course of D2O. Using syringe pump for stable infusion of 2ml/100g D2O and proton-density weighted RARE for dynamic imaging, intact brain morphology and good perfusion contrast were achieved in location with severe susceptibility effect.