Alessandro Proverbio1, Bernard M. Siow2, Daniel Alexander3, Adam Gibson1
1Department of Medical Physics and Bioengineering, University College London, London, United Kingdom; 2Centre for Advanced Biological Imaging, University College London, London, United Kingdom; 3Centre for Medical Image Computing and Department of Computer Science, University College London, London, United Kingdom
Non-invasive histology is a key research area. Diffusion NMR (dNMR) and Diffuse Optical Spectroscopy (DOS) can provide complementary information about the microstructure of a tissue using different contrast mechanisms. Here, we developed a biophysical model of the microstructure directly informed by dNMR and DOS signals, and we applied it to a sample to estimate three microstructural parameteres. This is a proof of concept that a low level combination of information obtained from dNMR and DOS can improve the accuracy of parameters estimatation. The model was developed in order to allow an extention to real tissues microstructure.