Peter F. Neher1, Bram Stieltjes2, Frederik B. Laun3, Hans-Peter Meinzer1, Klaus Hermann Fritzsche1, 2
1Medical and Biological Informatics, German Cancer Research Center (DKFZ), Heidelberg, Germany; 2Quantitative Image-based Disease Characterization, German Cancer Research Center (DKFZ), Heidelberg, Germany; 3Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
We present an interactive graphical tool, Fiberfox, to generate arbitrary fiber configurations and corresponding diffusion weighted images (DWI). The intuitive user interface allows for the generation of any number of straight, bended, crossing, kissing, twisting and fanning fiber bundles, simply by placing 3D-ROIs used as waypoints for the synthetic fibers. From these fibers, a DWI is calculated applying a user defined number of gradient directions, b-value, SNR, image size and spacing. Fiberfox is implemented in the open source medical imaging interaction toolkit (MITK) and will also be available as free download included in the next release of MITK Diffusion.