1iMinds-VisionLab, University of Antwerp, Antwerp, Belgium; 2Biomedical Imaging Group Rotterdam, Erasmus MC - University Medical Center Rotterdam, Rotterdam, Netherlands
Diffusion MRI typically employs large voxels to obtain sufficiently high SNR. Given the large voxel sizes, many voxels consist of a mixture of signals from different anatomical structures. To reduce the partial volume effect and retain high SNR, we propose a super resolution acquisition and reconstruction technique that directly computes high SNR and high resolution DTI parameters from a set of low resolution diffusion MRI data sets. Using simulations we show our technique outperforms direct high resolution acquisition and current super resolution reconstruction techniques which don't take into account the underlying diffusion model.