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Abstract #3234

Direct Non-Invasive MRI Measurement of the Absolute CBV-CBF Relationship During Sensory-Motor and Auditory Stimulation in Normal Humans

Pelin Aksit Ciris1, Maolin Qiu1, Robert Todd Constable1

1Diagnostic Radiology, Yale University, New Haven, CT, United States

BOLD signal reflects changes in CBV, CBF, blood oxygenation and metabolism, the quantification and physiological interpretation of which typically assumes that CBV=0.88CBF0.38 based on PET monkey measurements by Grubb et al. In this study, the absolute CBV-CBF relationship was measured directly in MRI non-invasively on 15 volunteers during sensory-motor and auditory stimulation. Measurements were within physiologically expected ranges, consistent with prior publications. Non-invasive characterization of the CBV-CBF relationship in humans under various metabolic or functional challenges can advance understanding of fMRI signal mechanisms, with further potential clinical utility in vascular state or treatment monitoring.