Alexandre Coimbra1, Farshid Faraji2, Alex De Crespigny1, David Clayton2
1Genentech Inc, South San Francisco, CA, United States; 2Genentech, Inc., South San Francisco, CA, United States
In single-site studies, brain functional connectivity metrics (FCMs) measured by resting-state functional MRI (rs-fMRI) have been reported to be sensitive to Alzheimer Disease (AD, ), beta-amyloid burden , and therapeutic effect . Exploratory RS-fMRI was included in two global Phase II studies of a novel AD amyloid drug. We studied different types of data processing pipelines and FCMs make recommendations based on ensuing FCMs test-retest performance and ability to differentiate cohorts scanned at 1.5T vs. 3T magnets. A discussion on FCMs and statistical power to detect changes due to disease progression and/or therapeutic effect is also provided.