CBF Modulation of Task-Positive and Task-Negative BOLD Responses to a Cognitive Task: Differential Effects in the Default Mode Network

Ashley D. Harris¹, Kevin Murphy¹, Richard G. Wise¹

Using a working memory task, the modulation the BOLD response at different resting CBF is examined in regions associated with the task activation and deactivation. Task activation is reduced with increased baseline CBF as expected from modelling. Task deactivation differs regionally; the default mode network has increased task deactivation while other task-negative regions show less deactivation.