Helen Erica D'Arceuil1, Alexandre Coimbra2, Pamela Triano3, Margaret Dougherty3, Julie Mello3, Michael E. Moseley4, Gary H. Glover, Maarten Lansberg5, Francis Blankenberg6
1Diagnostic Radiology, Stanford, Stanford, CA, United States; 2Genentech Inc, South San Francisco, CA, United States; 3Department of Rehabilitation Services, Stanford Hospital and Clinics, Stanford, CA, United States; 4Diagnostic Radiology, Stanford University, Stanford, CA, United States; 5Neurology and Neurological Sciences, Stanford Stroke Center, Stanford Hospital and Clinics, Stanford, CA, United States; 6Pediatric Radiology, Stanford Hospital and Clinics, Palo Alto, CA, United States
Enhanced task-based fMRI signals in primate and human brains, compared to the BOLD effect, have been realized using Ferumoxytol. We explored the use of ferumoxytol as a susceptibility contrast agent for CBV weighted resting state fMRI in 6 volunteers at 3T. While the amplitude of low frequency fluctuations was greater post ferumoxytol, the mean z-score and volume of visual and default mode networks were similar for BOLD and CBV weighted scans. CBV-RS-fMRI is robust and may be suitable for use in neurologically impaired or head trauma patients where regional tissue loss renders task FMRI problematic or even untenable.