Gene Young Cho1, 2, Ana Paula Klautau Leite3, Steven Baete3, Daniel K. Sodickson3, Sungheon Kim3, Linda Moy4, Eric E. Sigmund3
1Radiology - Center for Biomedical Imaging, New York University, New York, NY, United States; 2Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY, United States; 3Radiology - Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States; 4Radiology - Cancer Institute, New York University School of Medicine, New York, NY, United States
Diffusion tensor imaging (DTI) provides microstructural biomarkers reflecting diffusion anisotropy. DTI has been shown to probe anisotropic diffusion in the ducts of mammary fibrograndular tissue (FGT) and its disruption in breast cancer lesions. We explored the use of longer diffusion times to increase apparent restriction and enhance distinction between mammary FGT and lesion tissue. We collected stimulated echo DTI at two diffusion times (30 ms and 520 ms) in FGT and cancerous lesions and compared DTI measurements with typical clinical radiological data. Results indicate significantly higher FGT anisotropy at higher diffusion times and slightly increased lesion / FGT distinction.