Xia Li1, Lori
R. Arlinghaus1, A. Bapsi Chakravarthy1, Richard G.
Abramson1, Vandana G. Abramson1, Jaime Farley1,
Gregory D. Ayers1, Ingrid A. Mayer1, Mark C. Kelley1,
Ingrid M. Meszoely1, Julie Means-Powell1, Ana M. Grau1,
Melinda Sanders1, Sandeep R. Bhave2, Thomas E.
Yankeelov1
1Vanderbilt
University, Nashville, TN, United States; 2Washington University
in St. Louis, St. Louis, MO, United States
DCE-MRI and DW-MRI have been used to predict treatment response in breast cancer. However, in general, quantitative DCE- or DW-MRI parameters are investigated separately and it is not well studied if their combination could improve the diagnostic accuracy to predict the response of primary breast cancer to neoadjuvant therapy. In this study, we attempted to determine if quantitative changes in both DCE-MRI and DW-MRI following a single cycle of chemotherapy can be used to separate responders from non-responders. The results show that the combination of DCE- and DW-MRI improves the ability to predict treatment response than either method alone.