Sudath Hapuarachchige1, 2, Yoshinori Kato1, 3, Dmitri Artemov1, 3
1Division of Cancer Imaging Research, Russell H. Morgan Department of Radiology and Radiological Sc., The Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2In vivo Cellular Molecular Imaging Program, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; 3Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States
We have demonstrated that oscillating gradients of magnetic field induce significant damage to cells labeled with magnetic nanoparticles, such as superparamagnetic iron oxide (SPIO), in the presence of saturating static magnetic field. Specific labeling of cells with iron oxide can be achieved either by internalization of nanoparticles using standard cell transfection reagents and techniques or by modifying the cell surface with targeted magnetic nanoparticles. This novel treatment procedure, called GIFT (gradient-induced Fe therapy), can be implemented on a standard MRI system that makes the technology applicable for clinical use.