Wei-Ching Lo1, Karupppasamy Subburaj1, Lorenzo Nardo1, Sharmila Majumdar1, Michael Ries2, Xiaojuan Li1
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; 2Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA, United States
Along with the efforts of developing prevention strategies and new treatment methods for osteoarthritis, there are increasing demands for early diagnosis and critical treatment monitoring of cartilage degeneration in osteoarthritis. As a non-invasive imaging technique, it would be critical to link the biochemical analysis with in vivo imaging measures. This study developed a robust registration algorithm for in vivo and ex vivo cartilage imaging to explore the link between imaging measures and biochemical analysis.