Jie Zheng1, Mary K. Hasting1, David Muccigrosso1, Darrah Snozek1, Zhaoyang Fan2, John Curci1, Michael Mueller1
1Washington University in St. Louis, Saint Louis, MO, United States; 2Cedars-Sinal Medical Center, Los Angelas, CA, United States
A non-contrast MRI perfusion angiosome method was developed to assess skeletal muscle perfusion in feet. The study was performed in healthy volunteers and age-matched patients with diabetes mellitus, at rest and during a foot challenge. Significant attenuations in muscle perfusion reserve were observed in diabetic feet, even without developing foot ulcers.