Martin T. Freitag1, Thomas van Bruggen2, Klaus Hermann Fritzsche2, Romy Henze3, Romuald Brunner3, Peter Parzer3, Franz Resch3, Bram Stieltjes1
1Quantitative Imaging-based Disease Characterization, German Cancer Research Center, Heidelberg, Baden-Wuerttemberg, Germany; 2Division of Medical and Biological Informatics, German Cancer Research Center, Heidelberg, Baden-Wuerttemberg, Germany; 3Department of Child and Adolescent Psychiatry, Section Disorders of Personality Development, University Clinic Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany
Schizophrenia could result from failure of correct lateralization and lead to white matter misconnectivity. Previously, white matter alterations were described in the cerebellum, the visual system and in the corpus callosum. We investigated these regions using TBSS and evaluated potential changes in lateralization of the optic radiation and the superior cerebellar peduncle. A reduction of fractional anisotropy in the whole corpus callosum and the optic radiation and a decreased lateralization of the optic radiation and the superior cerebellar peduncles were observed. Our findings substantiate the concept that schizophrenia is a neurodevelopmental disorder which affects fiber connectivity and white matter lateralization.