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Abstract #3599

7-Tesla GRE Imaging of Hippocampal Subregion Thickness Is Associated with Symptom Severity and Neurocognitive Deficits in Major Depressive Disorder

Tracy L. Luks1, Yan Li1, Angela Jakary1, Erin Gillung2, Natalie M. Holbrook2, Stuart Eisendrath2, Pratik Mukherjee1, Sarah J. Nelson3

1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States; 2Langley Porter Psychiatric Institute, San Francisco, CA, United States; 3Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, United States


We used 7T MRI gradient-echo imaging to examine the thickness of 2 regions within hippocampal CA1, the cell-body layer stratum pyramidale (SP) and the synaptic layer stratum radiatum/stratum lacunosum-moleculare (SRLM) in Major Depressive Disorder patients, and to test the hypothesis that decreases in these ultra-high field MRI measures of hippocampal thickness would be significantly associated with increases in clinical symptom severity and deficits in memory and attention neurocognitive measures known to involve hippocampal function.