A Clinical Evaluation of a Novel, Retrospective and Entropy-Based Intensity Inhomogeneity Correction Method in 3T MRI

Sven Jaeschke¹, ², Alexander Hubert³, Andreas J. Bartsch⁴, Antje Kickhefel², Aleksandar Petrovic²

Intensity inhomogeneities remain an issue in high-field MRI and can degrade clinical interpretability of images. To improve image quality in a fast, robust and fully automated fashion, we developed and clinically validated a novel image inhomogeneity correction method, based on entropy minimization. A wide range of different MR-contrasts/sequences in healthy-control and images with pathological findings were assessed. Two trained radiologists evaluated each image in a blind fashion and both agreed on each rating. We show that the combination of the 3D implementation of our method and the current built-in Siemens solution significantly improves the clinical impression of 3T neuroradiological MRI.