Wenlong Xu1, Krishna Kattel1, Md. Wasi Ahmad1, Badrul Alam Bony1, Tirusew Tegafaw1, Woo Choul Heo1, Cho Rong Kim1, Yongmin Chang2, Gang Ho Lee1
1Department of Chemistry, Kyungpook National University, Buk-gu, Daegu, Korea; 2Department of molecular medicine, Kyungpook National University, Buk-gu, Daegu, Korea
A dual imaging now emerges as a new and advanced imaging technique in clinical applications. The single-phase mixed DyEuO3 and HoEuO3 nanoparticles are potential candidates for dual imaging experiment. It is expected that it will play a key role to diagnose diseases by replacing conventional single-imaging techniques. For example for MRI-FI dual imaging, the fluorescence imaging can be used to locate a disease and then MRI can be used to obtain high resolution MR images around the disease. We developed a facile synthesis of ultra-small D-Glucuronic acid coated Eu3+ doped Dysprosium oxide nanoparticles and Holmium oxide nanoparticles. The capability of nanoparticles as T2 MRI contrast agent was proved in vivo through T2 MR images of a rat. The fluorescent images were observed in vitro by taking DU145 and NCTC1469 cells. The nanoparticles exhibited no appreciable cytotoxicity up to 100 &[mu]M concentrations and in vivo MR experiment showed the negative contrast enhancement on mouse liver and kidneys after the injection of nanocolloid. Hence, it can be used as a fluorescence imaging agent as well as a T1 MRI contrast agent.