Dirk Krueger1, Gorka Salas2, Macarena Calero2, Silvia Lorrio Gonzlez1, Angeles Villanueva2, Mara P. Morales3, Ren M. Botnar1
1Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom; 2Instituto IMDEA Nanociencia, Madrid, Spain; 3Instituto de Ciencia de Materiales de Madrid, CSIC, Madrid, Spain
The aim of this project is to develop and validate multifunctionalised magnetic nanoparticles (MF-MNP) to selectively target and monitor delivery and treatment response of MNPs to cancer cells by MRI. We assessed eight MNPs on their MR imaging properties and investigated their effects on various cancer cell lines. The investigated 15 nm DMSA-coated MNP shows promising imaging (i.e. r1 and r2 relaxivities) and labelling properties without affecting viability of the cells and thus warrant in-vivo investigation in nude tumour bearing mice (BT474, MDA-MB-231, BxPc-3 PANC-1) to evaluate biodistribution, specificity and suitability for in vivo imaging and therapy.