Vickie Zhang1,
2, Robert A. Bok3, Jessie Lee2, Subramaniam
Sukumar1, Adam Cunha4, I-Chow Hsu4, Jean
Pouliot4, Daniel B. Vigneron1, 2, John
Kurhanewicz1, 2
1Department
of Radiology and Biomedical Imaging, University of California, San Francisco,
San Francisco, CA, United States; 2Graduate Program in
Bioengineering, University of California, San Francisco & University of
California, Berkeley, Berkeley, CA, United States; 3Department of
Radiology and Biomedical Imaging, University of California San Francisco, San
Francisco, CA, United States; 4Department of Radiation Oncology,
University of California, San Francisco, San Francisco, CA, United States
Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) has shown great clinical potential for assessing prostate cancer presence and aggressiveness prior to and after radiation therapy. Co-polarization of 13C pyruvate and urea also allows the simultaneous assessment of tumor perfusion and metabolism in a single MR acquisition (3,4). However, whether hyperpolarized 13C urea provides the same information as DCE MRI remains to be answered. This study investigated tumor perfusion prior to therapy and following radiation therapy in a transgenic murine model of prostate cancer using both HP 13C urea and DCE-MRI.