Ulrich Kllisch1, Rolf F. Schulte2, Markus Durst1, Jan Henrik Ardenkjaer-Larsen3, Francesca Frijia4, Luca Menichetti5, Massimo Lombardi4, Axel Haase1, Florian Wiesinger2
1Institute of Medical Engineering, Technische Universitt Mnchen, Garching, Germany; 2GE Global Research, Garching, Germany; 3GE Healthcare, Brndby, Denmark; 4Fondazione CNR-Regione Toscana G.Monasterio, Pisa, Italy; 5Institute of Clinical Physiology of CNR, Pisa, Italy
Metabolic imaging with hyperpolarized [1-13C]pyruvate has high potential for examination of myocardial viability. In this work a 3D cardiac sequence for imaging the metabolism of hyperpolarized [1-13C]pyruvate over the whole porcine heart is presented. Therefore a multiband pulse was implemented using the polarization very efficiently. The results demonstrate, that the presented acquisition scheme is feasible for [1-13C]pyruvate metabolic imaging by accurately depicting pyruvate lactate and bicarbonate distributions over the entire left ventricle.