Kelvin Billingsley1,
Sonal Josan1, 2, Jae Mo Park1, 3,
Yi-Fen Yen1, Ralph Hurd4, Dirk Mayer1,
2, Dwight G. Nishimura3, James Brooks5, Daniel
Spielman1, 3
1Department
of Radiology, Stanford University, Stanford, CA, United States; 2Neuroscience
Program, SRI International, Menlo Park, CA, United States; 3Department
of Electrical Engineering, Stanford University, Stanford, CA, United States; 4Applied
Science Laboratory, GE Healthcare, Menlo Park, CA, United States; 5Department
of Urology, Stanford University, Stanford, CA, United States
This work investigates a new biomarker, branched-chain amino transaminase (BCAT) activity, in prostate cancer. In addition, the feasibility of imaging the metabolism of hyperpolarized [1-13C]-KIC in human prostate cancer cell line-derived xenografts is explored.