Jae Mo Park1,
2, Sonal Josan, 13, Taichang Jang4, Milton
Merchant4, Ronald D. Watkins1, Yi-Fen Yen1,
Ralph Hurd5, Lawrence Recht4, Daniel Spielman1,
2, Dirk Mayer1, 3
1Radiology,
Stanford University, Stanford, CA, United States; 2Electrical Engineering,
Stanford University, Stanford, CA, United States; 3Neuroscience
Program, SRI International, Menlo Park, CA, United States; 4Neurology
and Neurological Science, Stanford University, Stanford, CA, United States; 5Applied
Science Laboratory, GE Healthcare, Menlo Park, CA, United States
We developed a fast volumetric chemical shift imaging sequence for imaging of hyperpolarized [2-13C]Pyruvate and its products, without suffering chemical shift displacement artifact due to the large spectral dispersion of [2-13C]Pyruvate and its products, and applied it to measuring brain metabolism in healthy and C6 glioma-bearing rats.