Marc S. Ramirez1, Jaehyuk Lee1, Vlad Sandulache2, Christopher M. Walker1, Yunyun Chen3, Stephen Y. Lai3, James A. Bankson1
1Department of Imaging Physics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States; 2Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, TX, United States; 3Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States
The use of multislice projection acquisitions for hyperpolarized 13C MRI is evaluated, where dynamic time courses and spatial images from multiple metabolites may be simultaneously derived from one acquisition. This strategy reduces the high preparation costs and injected tracer volume associated with separate spatial and dynamic hyperpolarized acquisitions. Projection acquisition strategies based on echo-planar spectroscopic imaging (EPSI) and multiband frequency encoding (MBFE) MRI are compared and used to extract vascular input functions and conversion kinetics of hyperpolarized pyruvate and lactate in mice bearing anaplastic thyroid tumors.