Angle Lecocq1, Yann Le Fur1, Andrew A. Maudsley2, Sulaiman Sheriff2, Mohammad Sabati2, Virginie Callot3, Monique Bernard4, Maxime Guye1, Jean-Philippe Ranjeva1
1CRMBM, CNRS, Aix-Marseille Univ, MARSEILLE, France; 2Department of radiology, Miller School of Medicine, University of Miami, MIAMI, FL, United States; 3Aix-Marseille University, MARSEILLE, France; 4Aix-Marseille Universit, MARSEILLE, France
Detection of abnormal global quantification of metabolites in case of diffusive pathologies, or abnormal metabolites spatial distribution for local pathologies, required the knowledge of variations in metabolites relative concentration across whole healthy brains. Nevertheless, there is a lack of metabolite quantitative information using a short echo time technique. In this study, we aimed to provide normative values of three major metabolites (Choline, N-Acetyl-Aspartate and Creatine) using a recent whole brain MRSI sequence called Echo Planar Spectroscopy Imaging (EPSI) with short echo time (20ms).