Bin Yang1, Li
Wang1, Chunmei Xia2, Lixia Yang3, Zhongwei
Qiao1, Ed X. Wu4
1Department
of Radiology, Children Hospital of Fudan University, Shanghai, China; 2Department
of Physiology and Pathophysiology, Fudan University, Shanghai, China; 3Department
of Radiology, Xuhui Center Hospital, Shanghai, China; 4Department
of Electrical and Electronic Engineering, The University of Hong Kong, Hong
Kong, China
This study aims to investigate the alteration of D, D* and perfusion faction (f) in the rat liver fibrosis with biliary duct ligation by using IVIM DW-MRI. We observed a decreasing trend of D, f and ADC of the livers from D0 to D3, D7. And the differences in D, f and ADC approached statistical significance on D7 compared to D0. There was no difference in D* of the livers from D0 to D3, D7. The reduction of true diffusion and perfusion faction would be attributed to alteration of hepatic microcirculation, portal inflammation at the early stage of liver fibrosis.