Lauren M.B. Burke1, Xiaodong Zhong2, Ghaneh Fananapazir1, Brian M. Dale3, Dominik Nickel4, Stephan A.R. Kannengiesser4, Mustafa R. Bashir1
1Radiology, Duke University Medical Center, Durham, NC, United States; 2MR R&D Collaborations Siemens Healthcare, Atlanta, GA, United States; 3MR R&D Collaborations, Siemens Healthcare, Morrisville, NC, United States; 4Healthcare Sector Imaging & Therapy Division, Siemens AG, Erlangen, Germany, Germany
Quantification of lipid content during contrast-enhanced MR abdominal examinations would be clinically helpful in the evaluation of hepatic metabolism, particularly if this could be accurately obtained following IV contrast administration without adding scan time to each individual patient. We investigated a 3D MRI technique with a multi-step adaptive fitting method for image reconstruction to measure liver proton density fat fraction. We compared this method on pre-contrast and post-contrast imaging with single voxel spectroscopy, and demonstrated a high correlation between the proton density fat fraction measured after contrast administration using the MRI method and both pre-contrast measurements.