Dinah S. Khatir1, Niels H. Buus1, Michael Pedersen2
1Department of Nephrology, Aarhus University Hospital, Aarhus, Denmark; 2MR Research Center, Aarhus University Hospital, Aarhus, Denmark
The objective of this study was to evaluate the reproducibility of measurements of renal artery blood flow (RABF) and intrarenal oxygenation (BOLD), using R2*, in patients (n=11) with chronic kidney disease (CKD) and healthy controls (n=9). This study showed that RABF and renal-cortical BOLD MRI were reproducible in both healthy volunteers and patients with CKD and hypertension. Furthermore, we found that inhalation of 100% oxygen significantly increased R2* in renal medulla in both groups. RABF and R2* measurements may serve as an sensitive biomarker for hemodynamic monitoring in CKD patients suffering from hypertension.