Farhad Pashakhanloo1, Michael Schr2, Roy Beinart3, M. Muz Zviman3, Henry Halperin4, Susumu Mori5, Neville D. Gai6, David A. Bluemke6, Elliot R. McVeigh1, Daniel A. Herzka7
1Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States; 2Philips Healthcare, Cleveland, OH, United States; 3Department of Medicine, Cardiology, Johns Hopkins University, School of medicine, Baltimore, MD, United States; 4Department of Medicine, Cardiology, Johns Hopkins University, Baltimore, MD, United States; 5Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD, United States; 6Radiology & Imaging Sciences, National Institutes of Health, Bethesda, MD, United States; 7Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States
High resolution DTI is a promising tool to study the myofiber remodeling in different disease models, specifically myocardial infarction (MI). Most studies of microstructure utilize either high field magnets and small animals hearts or pieces of large animal hearts. To our knowledge, this is the first study that incorporates sub-millimeter 3D DTI to study the remodeling around the infarct area in large animal models and suitable for whole human heart imaging. The extent of microstructural remodeling illustrated by this method is critical information in the pathophysiology of infarct and could be used to predict further electromechanical dysfunction developed after MI.