David Chen1, Behzad Sharif1, Afsaneh Haftbaradaran1, Melody Zaya1, Chrisandra Shufelt1, Puja Mehta1, Daniel S. Berman1, Louis EJ Thomson1, Debiao Li1, Noel Bairey Merz1
1Cedars Sinai Medical Center, Los Angeles, CA, United States
Myocardial perfusion reserve (MPR) acquired using first-pass cardiac MRI is a measure of the severity of microvascular coronary dysfunction (MCD) in subjects with signs and symptoms of ischemia but no obstructive coronary artery disease (CAD). Semi-quantitative measures (upslopes) have been used to analyze MPR data in the previous work. In this work, we propose using a fully quantitative myocardial blood flow (MBF) analysis to evaluate whether MPR is different between subjects with MCD and normal controls. MPR measured by quantitative MBF analysis provides better detection of MCD than that using semi-quantitative upslopes.