Mark A. Ahlman1, Scott Penzak2, Fabio Raman1, Jianing Pang3, Songtao Liu1, Debiao Li3, David A. Bluemke1
1Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States; 2Pharmacy, National Institutes of Health, Bethesda, MD, United States; 3Bioengineering, Cedars-Sianai Medical Center, Los Angeles, CA, United States
We proposed and validated a mathematically derived injection protocol for an intravascular contrast agent (Gadofosveset) that results in near constant blood T1 time over 5-6 minutes. Such an injection protocol should be idea for a 3D radial coronary MRA sequence with self-navigation. Using this model, we give evidence for proof-of-concept of the clinical applicability of our injection technique in humans.