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Abstract #0005

In-vivo Mapping of transcranial Direct Current Stimulation(tDCS) of Human Brain using MRI

Mayank V Jog 1 , Robert Smith 2 , Kay Jann 2 , Walter Dunn 3 , Allan Wu 2 , and Danny JJ Wang 2

1 Biomedical Engineering, University of California Los Angeles, Los Angeles, California, United States, 2 Neurology, University of California Los Angeles, Los Angeles, California, United States, 3 Psychiatry, University of California Los Angeles, Los Angeles, California, United States

Transcranial Direct Current Stimulation (tDCS) is a neuromodulation technique shown to have applications in stroke, pain-relief and cognition. tDCS is attractive as a treatment modality since it involves low currents and basic electrode placement on the surface of the head. To date, only mathematical modeling has been used to study tDCS-induced currents on the brain. We used MRI field mapping for in-vivo visualization of tDCS-induced electric currents (Basis: Amperes law). Utilizing concurrent tDCS-MRI with a Real/Sham paradigm, we observed significant magnetic field or phase changes in the brain parenchyma providing imaging evidence that tDCS effects do penetrate inside the brain.

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