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Abstract #0006

Reproducibility of 2-hydroxyglutarate spectroscopic imaging in IDH-mutated glioma patients at 3.0 T in vivo

Sandeep K Ganji 1,2 , Zhongxu An 1 , Akshay Madan 1 , Elizabeth A Maher 3,4 , and Changho Choi 1,2

1 Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2 Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 3 Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, 4 Harold C. Simmons Cancer Center, UT Southwestern Medical Center, Dallas, TX, United States

Recent studies have developed several techniques for measurement of 2-hydroxyglutarate (2HG) levels in brain gliomas and substantiate 2HG levels as a useful clinical biomarker. However for transitioning these methods to routine clinical use and obtain clinically significant results requires rigorous validation and testing. The purpose of this study was to perform repeated measurement of 2HG levels in a group of glioma patients and to determine intersession reproducibility, and repeatability.

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