Abstract #0045
Assessment of the Tumor Type-Specific Microenvironment Lactate, Vascularity, Hypoxia, Extracellular pH
Ellen Ackerstaff 1 , Natalia Kruchevsky 1 , Ekaterina Moroz 1 , Nirilanto Ramamonjisoa 1 , Rui V. Simoes 1 , H. Carl LeKaye 1 , Kristen L. Zakian 1 , Hansol Lee 2 , HyungJoon Cho 2 , Radka Stoyanova 3 , Inna Serganova 1 , Ronald G. Blasberg 1 , and Jason A. Koutcher 1
1
Memorial Sloan-Kettering Cancer Center, New
York, NY, United States,
2
Ulsan
National Institute of Science and Technology, Ulsan,
Korea,
3
Miller
School of Medicine, University of Miami, Miami, FL,
United States
A hostile tumor microenvironment impacts tumor growth,
progression, metastases, and treatment resistance. More
aggressive tumors have been associated with increased
lactate production, acidity, and suppressed T-cell
immune response. Here, we characterize noninvasively
in
vivo
the
tumor microenvironment in tumor models of different
origin and aggressivity and investigate the relationship
of lactate metabolism, vascularity, hypoxia, and
extracellular pH (pHe) to tumor type / aggressivity,
using
1
H
MRI/MRS/MRSI. Our data suggest that pHe does not
directly relate to tumor lactate levels and that
interplay of tumor metabolic activity and
vascularization regulates tumoral pHe, showing the
importance to assess these parameters independently.
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