Is R1 of Lipids related to pO2? Lessons from two tumor models
Florence Colliez 1 , Marie-Aline Neveu 1 , Julie Magat 1 , Thanh Trang Cao Pham 1 , Bernard Gallez 1 , and Bndicte F Jordan 1
Louvain Drug Research Institute, Biomedical
Magnetic Resonance Research Group, University of
Louvain, Brussels, Belgium
Variations in T1 and T2* are potentially valuable MRI
tools to follow changes in tumor oxygenation. T2* is
sensitive to the relative Hb/HbO2 ratio in vessel, while
T1 change is sensitive to dissolved oxygen which acts as
a T1-shortening paramagnetic contrast agent. The aim of
the current work is to investigate the quantitative
aspect of a new oxygen mapping method: MOBILE. Two tumor
models were submitted to (i) hyperoxic challenges
induced by carbogen breathing and (ii) hypoxic
challenges induced by Combetastatin A-4 Phosphate.
Actual pO2 values were obtained by EPR oximetry and
significantly correlated to Lipids R1 values.
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