Abstract #0049
Probing cancer metabolism with hyperpolarized 5-13C-glutamine
Claudia Cabella 1 , Magnus Karlsson 2 , Carolina Canap 3 , Giuseppina Catanzaro 1 , Sonia Colombo Serra 1 , Luigi Miragoli 1 , Luisa Poggi 1 , Fulvio Uggeri 1 , Luca Venturi 3 , Pernille R. Jensen 2 , Mathilde H. Lerche 2 , and Fabio Tedoldi 1
1
CRB Bracco Imaging SpA, Colleretto Giacosa,
Torino, Italy,
2
Albeda
Research Aps, Copenhagen, Denmark,
3
University
of Torino, Torino, Italy
Glutamine metabolism is a key marker of cancer
development. In particular, strong correlations have
been reported between oncogene expression and activity
of the glutaminase enzyme. Hyperpolarized 13C-MR
spectroscopy can provide insight to glutamine metabolism
and should hence be a valuable tool to study changes in
glutaminase activity as tumours progress. This work
reports on an improved preparation of hyperpolarized
5-13C-glutamine, providing a highly sensitive MR marker.
Physiological tolerable glutamine solutions with
remarkable polarization levels were obtained by
dissolution and used to perform 13C metabolic analysis
in vivo in healthy and tumour bearing rats and for
testing pharmacological treatments in vitro.
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