Abstract #0056
Multi-centre reproducibility of diffusion MRI parameters for clinical sequences in the brain
Matthew Grech-Sollars 1 , Patrick W Hales 1 , Keiko Miyazaki 2 , Felix Raschke 3 , Daniel Rodriguez 4,5 , Martin Wilson 6 , Simrandip K Gill 6 , Tina Banks 7 , Dawn E Saunders 7 , Jonathan D Clayden 1 , Matt Gwilliam 2 , Thomas R Barrick 3 , Paul S Morgan 4,5 , Nigel P Davies 8 , James Rossiter 9 , Dorothee P Auer 4,5 , Richard Grundy 5 , Martin O Leach 2 , Franklyn A Howe 3 , Andrew C Peet 6 , and Chris A Clark 1
1
UCL Institute of Child Health, University
College London, London, London, United Kingdom,
2
CR
UK and EPSRC Cancer Imaging Centre, Institute of Cancer
Research and Royal Marsden Foundation Trust, Surrey,
United Kingdom,
3
Division
of Clinical Sciences, St George's, University of London,
London, United Kingdom,
4
Division
of Clinical Neuroscience, University of Nottingham,
Nottingham, United Kingdom,
5
The
Childrens Brain Tumour Research Centre, University of
Nottingham, Nottingham, United Kingdom,
6
School
of Cancer Sciences, University of Birmingham,
Birmingham, United Kingdom,
7
Department of
Radiology, Great Ormond Street Hospital for Children,
London, United Kingdom,
8
Imaging
and Medical Physics, University Hospitals Birmingham NHS
Foundation Trust, Birmingham, United Kingdom,
9
Electrical
& Computer Engineering, University of Birmingham,
Birmingham, United Kingdom
The reproducibility of diffusion MRI parameters, and
more specifically the apparent diffusion coefficient
(ADC), intra-voxel incoherent motion (IVIM) parameters
the diffusion coefficient (D) and perfusion fraction
(f), and diffusion tensor imaging (DTI) parameters
mean diffusivity (MD) and fractional anisotropy (FA),
was analysed across multiple centres using standard
clinical protocols. ADC, D, MD and FA were found to have
a good reproducibility and research studies can benefit
from incorporating multi-centre data without any loss of
reproducibility compared to what would be achieved from
a single scanner at a single site.
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