Abstract #0059
Plasticity of the Human Visual Pathways Formed by Ocular Gene Therapy
Manzar Ashtari 1 , Gary Hui Zhang 2 , Laura Cyckowski 1 , Philip Cook 3 , Amanda Viands 1 , Kathleen Marshall 4 , James Gee 3 , Albert Maguire 5 , and Jean Bennett 6
1
Radiology, Children's Hospital of
Philadelphia, Philadelphia, PA, United States,
2
Computer
Science, University College London, London, United
Kingdom,
3
Radiology, University of
Pennsylvania, Philadelphia, PA, United States,
4
CCMT,
Children's Hospital of Philadelphia, Philadelphia, PA,
United States,
5
Ophthalmology, University of
Pennsylvania, PA, United States,
6
Ophthalmology,
University of Pennsylvania, Philadelphia, PA, United
States
Visual deprivation and blindness are debilitating
disorders with no available treatment. Recently, retinal
gene therapy has successfully treated a group of
patients with Leber's congenital amaurosis (LCA) and has
profoundly affected the quality of their lives. Of all
sensory systems, vision provides the most information to
the brain and plays a central role in how we relate to
and interact with the world. Thus, the success of this
exciting treatment raises the question of the effect
this therapy may have on the brains visual pathways. We
have employed advanced functional and structural imaging
to answer this question.
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