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Abstract #0061

Basal ganglia-cortical structural connectivity in Huntingtons disease

Marianne J U Novak 1,2 , Kiran K Seunarine 3 , Clare R Gibbard 2,3 , Bogdan Draganski 4,5 , Karl Friston 1 , Sarah J Tabrizi 2,6 , and Christopher A Clark 3

1 Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom, 2 Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom, 3 Imaging and Biophysics, UCL Institute of Child Health, London, United Kingdom, 4 LREN, Dpartement des Neurosciences Cliniques, Universit de Lausanne, Switzerland, 5 Max-Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 6 National Hospital for Neurology and Neurosurgery, London, United Kingdom

Huntington's disease (HD) is a genetic condition that affects both the white and grey matter of the brain. Striatal volume loss is the earliest and most characteristic structural abnormality seen using brain imaging in HD. In this work we present a statistical approach that allows us to quantitatively compare connectivity patterns of subcortical nuclei between groups. We apply our technique to a Huntington's disease cohort and find structured differences in patterns of connectivity compared to healthy controls. Conversely, we see no significant differences between premanifest HD patients and controls, which suggests progressive changes to patterns of connectivity with disease progression.

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