Abstract #0064
High field MRS is more sensitive to progression of neurodegeneration than clinical decline in spinocerebellar ataxia type 1 (SCA1)
Dinesh K Deelchand 1 , Uzay E Emir 1,2 , Diane Hutter 1 , Christopher M Gomez 3 , Lynn E Eberly 4 , Khalaf O Bushara 5 , and Gulin Oz 1
1
Center for Magnetic Resonance Research,
University of Minnesota, Minneapolis, MN, United States,
2
FMRIB
Centre, Nuffield Department of Clinical Neurosciences,
University of Oxford, Oxford, United Kingdom,
3
Department
of Neurology, University of Chicago, Chicago, IL, United
States,
4
Division
of Biostatistics, School of Public Health, University of
Minnesota, Minneapolis, MN, United States,
5
Department
of Neurology, Medical School, University of Minnesota,
Minneapolis, MN, United States
In this study, MR spectroscopy was used to monitor
disease progression in SCA1 patients. Subjects were
scanned at baseline and after an ~18 month follow-up on
3 T. We found that in pons, [tNAA]/[Ins] was
significantly reduced in SCA1 at visit #2 vs. visit #1
while no difference was detected in controls. The change
in ataxia rating scale between the two visits did not
reach significance suggesting that MRS is more sensitive
to detect a small change due to disease progression than
clinical assessment.
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