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Abstract #0071

Assessment of Macromolecular and Metabolic Alterations during Normal Brain Aging in the Dark Agouti Rat using 1H MRS at 17.2 Tesla

Alfredo Liubomir Lopez Kolkovsky 1 , Boucif Djemai 1 , and Fawzi Boumezbeur 1

1 CEA/Saclay/Neurospin, Commissariat a l'Energie Atomique, Gif-sur-yvette, Essonne, France

Normal brain aging is usually associated with a decline in brain function. Yet, the neural basis of age-related cognitive dysfunction in normal brain aging remains to be entirely elucidated. In this study, we sought to explore further these metabolic alterations in the brain of healthy rats with in vivo short echo time 1 H MRS at 17.2 T. Comparing metabolic profiles from young and elderly rats (1 and 16 months old respectively), it was found a decrease in neurotransmitters (Gln+Glu, GABA) and increase in Ins and tCho consistent with decline of neural function and chronic low-level glial activation consistent with previous observations in humans.

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