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Abstract #0097

Metabolic confinements in normal and stroked CNS in vivo revealed by localized double-Pulsed-Field-Gradient MRS at 21.1 T

Noam Shemesh 1 , Jens T Rosenberg 2,3 , Jean-Nicolas Dumez 1 , Samuel Colles Grant 2,3 , and Lucio Frydman 1,2

1 Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, 2 National High Magnetic Field Laboratory, The Florida State University, Tallahassee, FL, United States, 3 Chemical & Biomedical Engineering, The Florida State University, Tallahassee, FL, United States

Microstructural characterizations of the Central Nervous System are limited by waters non-specificity. Whereas diffusion Magnetic Resonance Spectroscopy (MRS) methods utilize a spectral dimension to impart specificity, they still rely on detection of Apparent Diffusion Coefficients (ADCs), whose relationship with underlying microstructural determinants are tenuous. Here, we combine a recent spectrally-specific Longitudinal Relaxation Enhancement (LRE) approach with the double-Pulsed-Field-Gradient (dPFG) approach that provides unambiguous and clear indications for restricted diffusion. The ensuing localized dPFG MRS provides unique signatures for metabolic confinements, which are shown to vary in stroked rats. These unique measurements provide a glimpse into the nature of ADC variations in stroke.

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