Multiple Echo and Inversion Time MPRAGE with Inner Loop GRAPPA Acceleration and Prospective Motion Correction for Minimally Distorted Multispectral Brain Morphometry
Andre J. W. van der Kouwe 1 , M. Dylan Tisdall 1 , Himanshu Bhat 2 , Bruce Fischl 1 , and Jonathan R. Polimeni 1
Radiology, Massachusetts General Hospital,
Charlestown, MA, United States,
Healthcare USA, Charlestown, MA, United States
Conventional MPRAGE suffers from blurring in the inner
phase encoding direction (between inversions) and
readout direction, due to T1 and T2* decay that broadens
the point spread functions in these directions,
respectively. This can be mitigated by combining
multiple GRAPPA accelerated phase encoding blocks and
multiple higher bandwidth echoes (shorter readouts that
also reduce susceptibility distortion), respectively.
This also enables estimation of absolute T1 and T2*
times for each voxel. To minimize blurring, real-time
prospective motion tracking with EPI volume navigators
is included. The resulting generalized MPRAGE sequence
provides high quality images for brain morphometry
without affecting total acquisition time.
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