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Abstract #0132

Imaging the developing brain at the bedside: A comparison of diffuse optical tomography and functional MRI

Silvina L. Ferradal 1 , Steve M. Liao 2 , Adam T. Eggebrecht 1 , Joshua S. Shimony 1 , Terrie E. Inder 3 , Joseph P. Culver 1 , and Christopher D. Smyser 2

1 Radiology, Washington University in St. Louis, St. Louis, MO, United States, 2 Pediatrics, Washington University in St. Louis, St. Louis, MO, United States, 3 Harvard Medical School, Boston, MA, United States

Adverse neurodevelopmental outcomes in preterm infants remain a clinical challenge. While functional connectivity (fc) using functional MRI opens a window to study brain function in neonates, frequent longitudinal monitoring is often restricted in the sickest infants. Diffuse optical tomography (DOT) provides a portable alternative modality for evaluating brain function at the bedside. Here we demonstrate that our DOT system generates resting-state maps exhibiting strong agreement with non-concurrent fcMRI maps in identical subjects. Our results suggest that fcDOT provides satisfactory spatial localization and resolution, and illustrates its potential as a viable imaging tool for bedside monitoring.

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