Meeting Banner
Abstract #0133

Hemiplegic cerebral palsy and constraint-induced movement therapy: Resting state functional magnetic resonance and diffusion tensor imaging predictors and neuroplastic changes

Kathryn Yvonne Manning 1 , Darcy Fehlings 2 , and Ravi S. Menon 3

1 Medical Biophysics, The University of Western Ontario, London, Ontario, Canada, 2 Holland Bloorview Kids Rehabilitation Hospital, University of Toronto, Toronto, Ontario, Canada, 3 Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada

Hemiplegic cerebral palsy patients experience learned non-use where the hemiplegic arm is further inhibited from healthy development as most tasks are performed with the unaffected limb. Constraint-induced movement therapy (CIMT) has rendered significant functional improvement in many patients, though not all experience success and little is known about the possible neurological predictors. Resting state functional MRI and diffusion tensor imaging reveal altered global network organization and quantify white matter tract integrity. Potential predictors of clinical success are identified, and resting state network reorganization after CIMT provides evidence of neuroplasticity.

This abstract and the presentation materials are available to members only; a login is required.

Join Here