Meeting Banner
Abstract #0149

Sensitivity of Multicomponent Driven Equilibrium Single Observation of T1 and T2 (mcDESPOT) to Magic Angle Effects in Bovine Articular Cartilage at 3.0T

Rajeev Chaudhary 1 , Fang Liu 2 , Nade Sritanyaratana 1 , Jarred M. Kaiser 3 , Samuel A. Hurley 2 , Walter F. Block 1,2 , and Richard X. Kijowski 4

1 Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 2 Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 3 Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 4 Radiology, University of Wisconsin-Madison, Madison, WI, United States

This study was performed to investigate the influence of the magic angle effect on multi-component T2 parameters measured using mcDESPOT. Ex-vivo articular cartilage specimens were imaged using mcDESPOT at angles of 0, 30, 55, and 60 relative to the main magnetic field. Percent changes in T2 parameters from 0 to 55 where there was maximum magic angle effect was 42.9% for single-component T2, 20.0% for T2 of bulk water loosely bound to the macromolecular matrix, 40.0% for the T2 of water tightly bound to proteoglycan, and -4.9% for the fraction of water tightly bound to proteoglycan.

This abstract and the presentation materials are available to members only; a login is required.

Join Here