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Abstract #0182

Correlation between cardiovascular T1 MRI, histology and future ventricular remodeling in ischemic heart disease.

Walter RT Witschey 1 , Jeremy R McGarvey 1 , Madonna Lee 1 , Francisco Contijoch 2 , Victor Ferrari 3 , Yuchi Han 3 , Julio A Chirinos 3 , Chikashi Aoki 1 , Satoshi Takebayashi 4 , Joseph H Gorman III 1 , James J Pilla 4 , and Robert C Gorman 1

1 Surgery, University of Pennsylvania, Philadelphia, PA, United States, 2 Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 3 Cardiology, University of Pennsylvania, Philadelphia, PA, United States, 4 Radiology, University of Pennsylvania, Philadelphia, PA, United States

T1rho MRI has been shown to detect myocardial fibrosis and has potential to be used as a biomarker for heart disease. The progression of T1rho relaxation times in inflammation, wound healing and scar have been reported for direct ligation animal models, mimicking only the most severe types of human ischemic heart disease. Our objective was to determine the relationship between T1rho relaxation times and pathology, at 1 day, 1 and 4 weeks post-infarction in an ischemia-reperfusion pig model. We found that there was a significant increase in T1rho relaxation times at 1 week in pigs and this was indicative of future ventricular remodeling. There was excellent correlation between T1rho MRI-determined infarction area, coronary artery perfusion watershed and fibrosis.

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